反应详情

温度

105 °C

A solution of tert-butyl 3-oxopyrrolidine-1-carboxylate (40 g, 216 mmol) was treated with DMF-DMA (267 g, 2241 mmol) and heated at 105° C. for 40 min. The solution was cooled and evaporated under reduced pressure and the resulting orange solid was treated with hexane (200 mL) and cooled in the refrigerator over the weekend. The resulting brownish-yellow solid obtained as such was collected by filtration, dried and used in the next step without further purification.

1. temperatureThe solution was cooled
2. customevaporated under reduced pressure
3. additionthe resulting orange solid was treated with hexane (200 mL)
4. temperaturecooled in the refrigerator over the weekend
5. customThe resulting brownish-yellow solid obtained
6. filtrationas such was collected by filtration
7. customdried
8. customused in the next step without further purification