Trifluoroacetic acid → HCID 178511733, compound

HRID 532533Notes

Reaction equation

HRID 532533 reaction equation
[N:1]1[NH:2][CH:3]=[C:4]2[CH2:8][N:7]([C@H:9]3[CH2:14][S:13](=[O:15])[CH:12]([C:16]4[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[C:17]=4[F:24])[C@@H:11]([NH:25]C(=O)OC(C)(C)C)[CH2:10]3)[CH2:6][C:5]=12.[C:33]([OH:39])([C:35]([F:38])([F:37])[F:36])=[O:34]>C(Cl)Cl>[F:36][C:35]([F:38])([F:37])[C:33]([OH:39])=[O:34].[N:1]1[NH:2][CH:3]=[C:4]2[CH2:8][N:7]([C@H:9]3[CH2:14][S:13](=[O:15])[CH:12]([C:16]4[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[C:17]=4[F:24])[C@@H:11]([NH2:25])[CH2:10]3)[CH2:6][C:5]=12

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acid2×HCID 178454096HCID 178454096, compound

Product 1

HCID 178511733HCID 178511733, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl N-[(3S,5R)-5-(4,6-dihydro-2H-pyrrolo[3,4-c]pyrazol-5-yl)-1-oxo-2-(2,3,5-trifluorophenyl)thian-3-yl]carbamate was dissolved in a mixture of TFA (0.02 mL) and methylene chloride (0.2 mL). After stirring at RT for 30 min, additional TFA (0.02 mL) was added and the mixture was stirred an additional 60 min at room temperature. The solvents were evaporated and the residue was freeze-dried from a mixture of benzene and ethanol to give the title compound as a white solid.

Workup

  1. stirringthe mixture was stirred an additional 60 min at room temperature
  2. customThe solvents were evaporated
  3. dry with materialthe residue was freeze-dried from a mixture of benzene and ethanol

Sources & evidence

ORD record
ord-250e8f03c48140969275d5f6d5f27006
Source dataset
uspto-grants-2014_10
Patent number
US08853212B2

Reaction notes

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