Hydrochloric Acid → HCID 71815094, compound

HRID 532623Notes

Reaction equation

HRID 532623 reaction equation
C[Si](C)(C)CCOC[N:7]1[C:11]2[C:12]3[CH:13]=[CH:14][S:15][C:16]=3[CH2:17][C:10]=2[C:9]([C:18]2[CH:19]=[C:20]([NH:24]C(=O)C)[CH:21]=[CH:22][CH:23]=2)=[N:8]1.[ClH:30]>CO>[ClH:30].[S:15]1[CH:14]=[CH:13][C:12]2[C:11]3[NH:7][N:8]=[C:9]([C:18]4[CH:19]=[C:20]([NH2:24])[CH:21]=[CH:22][CH:23]=4)[C:10]=3[CH2:17][C:16]1=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86699223HCID 86699223, compound

Product 1

HCID 71815094HCID 71815094, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
100 °C

Procedure

N-{3-[4-(2-Trimethylsilanyl-ethoxymethyl)-4,7-dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalen-6-yl]-phenyl}-acetamide (0.21 g, 0.5 mmol) was dissolved in MeOH and treated with concentrated HCl (0.16 mL, 5 mmol). The reaction mixture was heated at 100° C. for 4 hr. The solution was cooled to room temperature and the resultant precipitate was filtered, washed with MeOH and concentrated under reduced pressure to provide the corresponding 3-(4,7-Dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalen-6-yl)-phenylamine hydrochloride (0.12 g, 0.41 mmol) as yellow solid in 81% yield.

Workup

  1. temperatureThe solution was cooled to room temperature
  2. filtrationthe resultant precipitate was filtered
  3. washwashed with MeOH
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-d37da52173f14f908aa2ea193756b24a
Source dataset
uspto-grants-2014_10
Patent number
US08853207B2

Reaction notes

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