反应详情

温度

100 °C

6-(4-Methoxy-phenyl)-2-pyridin-4-yl-4-(2-trimethylsilanyl-ethoxymethyl)-4,7-dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalene (0.49 g, 0.98 mmol) was dissolved in MeOH and treated with concentrated HCl (0.3 mL, 9.4 mmol). The reaction mixture was heated at 100° C. for 4 hr. The solution was cooled to room temperature and the resultant precipitate was filtered, washed with MeOH and concentrated under reduced pressure to provide the corresponding 6-(4-Methoxy-phenyl)-2-pyridin-4-yl-4,7-dihydro-1-thia-4,5-diaza-cyclopenta[a]pent alene (0.35 g, 0.95 mmol) as brown solid in 98% yield.

1. temperatureThe solution was cooled to room temperature
2. filtrationthe resultant precipitate was filtered
3. washwashed with MeOH
4. concentrationconcentrated under reduced pressure