反应详情

温度

100 °C

6-(4-Methoxy-phenyl)-2-(6-methoxy-pyridin-3-yl)-4-(2-trimethylsilan yl-ethoxymethyl)-4,7-dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalene (0.35 g, 0.69 mmol) was dissolved in MeOH and treated with concentrated HCl (0.21 mL, 6.9 mmol). The reaction mixture was heated at 100° C. for 4 hr. The solution was cooled to room temperature and the resultant precipitate was filtered, washed with MeOH and concentrated under reduced pressure to provide the corresponding 6-(4-Methoxy-phenyl)-2-(6-methoxy-pyridin-3-yl)-4,7-dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalene (0.55 g, 0.6 mmol) as white solid in 87% yield.

1. temperatureThe solution was cooled to room temperature
2. filtrationthe resultant precipitate was filtered
3. washwashed with MeOH
4. concentrationconcentrated under reduced pressure