Boron tribromide → HCID 136274050, compound

HRID 532700Notes

Reaction equation

HRID 532700 reaction equation
B(Br)(Br)Br.C[O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:17]3[CH2:18][C:19]4[S:20][C:21]([C:24]5[CH:25]=[CH:26][C:27]([NH2:30])=[N:28][CH:29]=5)=[CH:22][C:23]=4[C:16]=3[NH:15][N:14]=2)=[CH:9][CH:8]=1>C(Cl)Cl>[NH2:30][C:27]1[N:28]=[CH:29][C:24]([C:21]2[S:20][C:19]3[CH2:18][C:17]4[C:13]([C:10]5[CH:11]=[CH:12][C:7]([OH:6])=[CH:8][CH:9]=5)=[N:14][NH:15][C:16]=4[C:23]=3[CH:22]=2)=[CH:25][CH:26]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 71815237HCID 71815237, compound

Product 1

HCID 136274050HCID 136274050, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

BBr3 (1.25 g, 5.0 mmol) was added to a solution of 5-[6-(4-Methoxy-phenyl)-4,7-dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalen-2-yl]-pyridin-2-ylamine (0.18 g, 0.5 mmol) in CH2Cl2 (8.0 mL). After 2 hours, the solution was evaporated and washed with EtOAc, filtered, and concentrated to give the corresponding 4-[2-(6-Amino-pyridin-3-yl)-4,7-dihydro-1-thia-4,5-diaza-cyclopenta[a]pentalen-6-yl]-phenol (0.14 g, 0.42 mmol) as brown solid in 84% yield.

Workup

  1. customthe solution was evaporated
  2. washwashed with EtOAc
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-5fc2bb901f8d4e97926f833cdfbf6bef
Source dataset
uspto-grants-2014_10
Patent number
US08853207B2

Reaction notes

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