Hydrochloric Acid → HCID 66617779, compound

HRID 532721Notes

Reaction equation

HRID 532721 reaction equation
[OH:1][C@H:2]1[C:6]2[N:7]=[CH:8][N:9]=[C:10]([N:11]3[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][C@@H:12]3[CH3:24])[C:5]=2[C@H:4]([CH3:25])[CH2:3]1.[ClH:26]>C(Cl)Cl>[ClH:26].[ClH:26].[CH3:25][C@H:4]1[C:5]2[C:10]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][C@@H:12]3[CH3:24])=[N:9][CH:8]=[N:7][C:6]=2[C@H:2]([OH:1])[CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59671070HCID 59671070, compound

Product 1

HCID 66617779HCID 66617779, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

T a solution of the (S)-tert-butyl 4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate (0.106 g, 0.304 mmol) in DCM (20 mL) was added HCl (4M in dioxane, 4 mL). The mixture was stirred at room temperature overnight. The solvent was removed to afford (5R,7R)-5-methyl-4-((S)-2-methylpiperazin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-7-ol dihydrochloride (0.098 g, 99%). MS (APCI+) [M+H] +249.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-1fa523e974d14b9e8760d12d1721a660
Source dataset
uspto-grants-2014_10
Patent number
US08853199B2

Reaction notes

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