Hydrochloric Acid → HCID 66893177, compound

HRID 532811Notes

Reaction equation

HRID 532811 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][C:16]=2[O:23][CH3:24])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:25]>O1CCOCC1>[ClH:25].[CH3:24][O:23][C:16]1[CH:17]=[C:18]([O:21][CH3:22])[CH:19]=[CH:20][C:15]=1[N:11]1[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59366192HCID 59366192, compound

Product 1

HCID 66893177HCID 66893177, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

300 mg of 4-(2,4-dimethoxyphenyl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester was dissolved in 10 mL of 4 N HCl in dioxane. The mixture was stirred at room temperature for 2 hrs and evaporated to dryness to give the desired product (270 mg) as a hydrochloride salt. MS (ES) m/z 237.2 (M+H+).

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-3d541dd72b8c454c91b8c2f74971fd9d
Source dataset
uspto-grants-2014_10
Patent number
US08853202B2

Reaction notes

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