Hydrochloric Acid → 1-(3-Methoxypyridin-2-yl)-[1,4]diazepane dihydrochloride

HRID 532814Notes

Reaction equation

HRID 532814 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[C:20]([O:21][CH3:22])=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23].O1CCOCC1>CO>[ClH:23].[ClH:23].[CH3:22][O:21][C:20]1[C:15]([N:11]2[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]2)=[N:16][CH:17]=[CH:18][CH:19]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 593662084-(3-Methoxypyridin-2-yl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester

Product 1

HCID 668934111-(3-Methoxypyridin-2-yl)-[1,4]diazepane dihydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 4-(3-methoxypyridin-2-yl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester (335 mg, 1.1 mmol) was added MeOH (3 mL) followed by 4M HCl in dioxane (5 mL, 20 mmol). This was stirred for 15 hours, then concentrated to give the title compound. MS (ES) m/z 208 (M+H+).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-68970de082864fc28415ab1918483439
Source dataset
uspto-grants-2014_10
Patent number
US08853202B2

Reaction notes

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