N-bromobutanimide → HCID 59612867, compound

Participants

Reaction Steps

A solution of 7-cyclopropylquinoline (3.45 g, 19.7 mmol) and NBS (4.03 g, 22.66 mmol) in DMF (50 mL) was heated at 65° C. for 2 h. The reaction was quenched with saturated aqueous NaHCO3 and extracted with EtOAc. The organic layer was separated, dried over anhydrous Na2SO4, concentrated, and purified by chromatography with a gradient elution of 1-10% EtOAc/CH2Cl2 to yield 8-bromo-7-cyclopropylquinoline (1.75 g, 35% yield).

Provenance & Evidence