反应详情

A solution of 7-cyclopropylquinoline (3.45 g, 19.7 mmol) and NBS (4.03 g, 22.66 mmol) in DMF (50 mL) was heated at 65° C. for 2 h. The reaction was quenched with saturated aqueous NaHCO3 and extracted with EtOAc. The organic layer was separated, dried over anhydrous Na2SO4, concentrated, and purified by chromatography with a gradient elution of 1-10% EtOAc/CH2Cl2 to yield 8-bromo-7-cyclopropylquinoline (1.75 g, 35% yield).

1. customThe reaction was quenched with saturated aqueous NaHCO3
2. extractionextracted with EtOAc
3. customThe organic layer was separated
4. dry with materialdried over anhydrous Na2SO4
5. concentrationconcentrated
6. custompurified by chromatography with a gradient elution of 1-10% EtOAc/CH2Cl2