Hydrogen Peroxide → HCID 86711414, compound

HRID 532967Notes

Reaction equation

HRID 532967 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[N:5]=[CH:6][N:7]([C:9]2[CH:32]=[C:14]3[C:15]4[C:20]([CH2:21][CH2:22][N:13]3[C:12](=[O:33])[CH2:11][N:10]=2)=[C:19](B2OC(C)(C)C(C)(C)O2)[CH:18]=[CH:17][CH:16]=4)[CH:8]=1.[OH:34]O>COCCOC>[OH:34][C:19]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:20]=1[CH2:21][CH2:22][N:13]1[C:12](=[O:33])[CH2:11][N:10]=[C:9]([N:7]3[CH:8]=[C:4]([CH2:3][O:2][CH3:1])[N:5]=[CH:6]3)[CH:32]=[C:14]12

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 86711415HCID 86711415, compound

Product 1

HCID 86711414HCID 86711414, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

Example 142-2. 2-(4-(methoxymethyl)-1H-imidazol-1-yl)-9-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7,8-dihydro-[1,4]diazepino[7,1-a]isoquinolin-5(4H)-one (413 mg, 0.737 mmol) was dissolved in DME (10 mL) and hydrogen peroxide (30%, 3.40 mL, 33.3 mmol) was added at rt. The mixture was stirred overnight and the resulting crystals were filtered off (62 mg). UPLC-MS: MS 339.2 (M+H+); UPLC rt 0.63 min.

Workup

  1. filtrationthe resulting crystals were filtered off (62 mg)
  2. customUPLC rt 0.63 min.

Sources & evidence

ORD record
ord-abce02ca1036481eb18b7c6b7f6f60dc
Source dataset
uspto-grants-2014_10
Patent number
US08853203B2

Reaction notes

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