HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Ethynyl-1,2,3-trimethoxybenzene → 2,4-Diamino-5-(2-(3,4,5-trimethoxyphenyl)ethynyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Ethynyl-1,2,3-trimethoxybenzene | HCID 11830260 | — |
| Reactant | 5-Iodopyrimidine-2,4-diamine | HCID 16110335 | — |
| Product | 2,4-Diamino-5-(2-(3,4,5-trimethoxyphenyl)ethynyl)pyrimidine | HCID 16110320 | 90% |
Reaction Steps
2,4-Diamino-5-iodopyrimidine (236 mg) was allowed to react with 5-Ethynyl-1,2,3-trimethoxybenzene (384 mg) as per the general procedure to afford 2,4-Diamino-5-(2-(3,4,5-trimethoxyphenyl)ethynyl)pyrimidine as a white powder (270 mg, 90%): Rf=0.28 (9:1, CHCl3:MeOH); mp=202-204° C.; 1H NMR (DMSO-d6) δ 7.94 (s, 1H), 6.90 (s, 2H), 6.37 (s, 2H), 3.79 (s, 6H), 3.67 (s, 3H); 13C NMR (DMSO-d6) δ 163.4, 162.2, 159.4, 159.2, 152.8, 137.6, 118.6, 108.3, 108.2, 94.7, 89.8, 83.4, 60.2, 60.1, 56.0, 55.9; Anal. (C15H16N4O3) C, H, N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853228B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-e4bd626713dd403dbffca7555f25406d |
| Source note | uspto-grants-2014_10 |