Trifluoroacetic acid → HCID 58329444, compound

HRID 533037Notes

Reaction equation

HRID 533037 reaction equation
[CH2:1]([N:3]1[C:18](=[O:19])[C:7]2[CH:8]=[N:9][C:10]3[C:11]([O:16][CH3:17])=[CH:12][CH:13]=[CH:14][C:15]=3[C:6]=2[N:5](CC2C=CC(OC)=CC=2)[C:4]1=[O:29])[CH3:2].FC(F)(F)C(O)=O>C(Cl)Cl>[CH2:1]([N:3]1[C:18](=[O:19])[C:7]2[CH:8]=[N:9][C:10]3[C:11]([O:16][CH3:17])=[CH:12][CH:13]=[CH:14][C:15]=3[C:6]=2[NH:5][C:4]1=[O:29])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58329389HCID 58329389, compound

Product 1

HCID 58329444HCID 58329444, compoundYield 83.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-Ethyl-7-methoxy-1H-pyrimido[5,4-c]quinoline-2,4-dione (25 mg) was prepared from 3-ethyl-7-methoxy-1-(4-methoxy-benzyl)-1H-pyrimido[5,4-c]quinoline-2,4-dione (50 mg, 0.11 mmol) via treatment of trifluoroacetic acid in DCM (1 mL). LCMS: m/z 272 [M+1]+.

Sources & evidence

ORD record
ord-2ad4a9103c0844beab8e471b9e019c7d
Source dataset
uspto-grants-2014_10
Patent number
US08853226B2

Reaction notes

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