HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-[5-(4-Methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid tert-butyl ester | HCID 86686880 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | 4-[5-(4-Methanesulfonylphenyl)-2,3-dihydrobenzofuran-2-yl]piperidine | HCID 67973289 | — |
Reaction Steps
A solution of HCl in dioxane (4 N, 5.0 mL) is added to 4-[5-(4-methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid tert-butyl ester (750 mg) in dichloromethane (1 mL) and the resulting mixture is stirred for 5 min at room temperature. The solvents are evaporated in vacuo to give the title compound as its hydrochloric acid salt. Mass spectrum (ESI+): m/z=358 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853239B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-95b4e8a38d3c430a99e87e7fe464c0df |
| Source note | uspto-grants-2014_10 |