5-(2-Fluoro-4-methanesulfonylmethyl-phenyl)-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine → 5-(2-Fluoro-4-methanesulfonylmethyl-phenyl)-2-{1-[(1-trifluoromethyl-cyclopropyl)methyl]-piperidin-4-yl}-2,3-dihydrofuro[2,3-c]pyridine

HRID 533132Notes

Reaction equation

HRID 533132 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH2:8][S:9]([CH3:12])(=[O:11])=[O:10])[CH:5]=[CH:4][C:3]=1[C:13]1[CH:14]=[C:15]2[CH2:21][CH:20]([CH:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)[O:19][C:16]2=[CH:17][N:18]=1.[F:28][C:29]([F:40])([F:39])[C:30]1([CH2:33]OS(C)(=O)=O)[CH2:32][CH2:31]1>>[F:1][C:2]1[CH:7]=[C:6]([CH2:8][S:9]([CH3:12])(=[O:10])=[O:11])[CH:5]=[CH:4][C:3]=1[C:13]1[CH:14]=[C:15]2[CH2:21][CH:20]([CH:22]3[CH2:27][CH2:26][N:25]([CH2:33][C:30]4([C:29]([F:40])([F:39])[F:28])[CH2:32][CH2:31]4)[CH2:24][CH2:23]3)[O:19][C:16]2=[CH:17][N:18]=1

Participants

3

Reactant 2

HCID 712081405-(2-Fluoro-4-methanesulfonylmethyl-phenyl)-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridineHCID 86649942(1-(Trifluoromethyl)cyclopropyl)methyl methanesulfonate

Product 1

HCID 715986545-(2-Fluoro-4-methanesulfonylmethyl-phenyl)-2-{1-[(1-trifluoromethyl-cyclopropyl)methyl]-piperidin-4-yl}-2,3-dihydrofuro[2,3-c]pyridine

Procedure

The title compound is prepared from 5-(2-fluoro-4-methanesulfonylmethyl-phenyl)-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine and methanesulfonic acid (1-trifluoromethyl-cyclopropyl)methyl ester following a procedure analogous to that described for Example 2. LC (method 1): tR=1.01 min; Mass spectrum (ESI+): m/z=513 [M+H]+.

Sources & evidence

ORD record
ord-8e0c9373f31844059facf76dd904404a
Source dataset
uspto-grants-2014_10
Patent number
US08853239B2

Reaction notes

Loading…