5-(2-Fluoro-4-methanesulfonylmethyl-phenyl)-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine → 5-(2-Fluoro-4-methanesulfonylmethyl-phenyl)-2-{1-[(1-trifluoromethyl-cyclopropyl)methyl]-piperidin-4-yl}-2,3-dihydrofuro[2,3-c]pyridine

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Reaction Steps

The title compound is prepared from 5-(2-fluoro-4-methanesulfonylmethyl-phenyl)-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine and methanesulfonic acid (1-trifluoromethyl-cyclopropyl)methyl ester following a procedure analogous to that described for Example 2. LC (method 1): tR=1.01 min; Mass spectrum (ESI+): m/z=513 [M+H]+.

Provenance & Evidence