HCID 86667501, compound → HCID 86667500, compound

HRID 533137Notes

Reaction equation

HRID 533137 reaction equation
[ClH:1].[Cl:2][C:3]1[N:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=[O:6]>S(Cl)(Cl)=O>[Cl:2][C:3]1[N:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:4]=1[C:5]([Cl:1])=[O:6]

Participants

3

Reactant 1

HCID 86667501HCID 86667501, compound

Product 1

HCID 86667500HCID 86667500, compoundYield 85.7%

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 2-chloro-6-methoxy-nicotinic acid hydrochloride salt (360 g, 1925 mmol) in thionyl chloride (500 mL) was stirred at 80° C. for 5 h. The solvent was evaporated in vacuo to yield 2-chloro-6-methoxy-nicotinoyl chloride (340 g, 85%).

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-2a8c33d8af8944d999a0bd277821af44
Source dataset
uspto-grants-2014_10
Patent number
US08853237B2

Reaction notes

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