2-Methoxy-7,8-dihydro-1,6-naphthyridin-5(6H)-one → HCID 178517695, compound

HRID 533141Notes

Reaction equation

C[O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:9](=[O:13])[NH:8][CH2:7][CH2:6][C:5]=2[N:4]=1>Br.CC(O)=O>[OH:2][C:3]1[CH:12]=[CH:11][C:10]2[C:9](=[O:13])[NH:8][CH2:7][CH2:6][C:5]=2[N:4]=1

Participants

Conditions

Temperature: 60 °C

Procedure

2-Methoxy-7,8-dihydro-6H-[1,6]naphthyridin-5-one (18 g, 101.1 mmol) was added to a mixture of HBr/CH3CO2H (60 mL). The mixture was stirred at 60° C. for 16 h. The solvent was evaporated in vacuo to yield 2-hydroxy-7,8-dihydro-1,6-naphthyridin-5(6H)-one (17 g, 68%) as an oil.

Workup

customThe solvent was evaporated in vacuo

Sources & evidence

ORD record: ord-6df093b6aa73465491d93276fd43d198
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08853237B2

Reaction notes

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