HCID 67774099, compound → HCID 178427225, compound

HRID 533422Notes

Reaction equation

HRID 533422 reaction equation
CC1(C)O[C:6](=[O:8])[C:5](=[CH:9][NH:10][C:11]2[CH:19]=[CH:18][C:14]([C:15]([OH:17])=[O:16])=[CH:13][C:12]=2[CH3:20])C(=O)O1>C1(OC2C=CC=CC=2)C=CC=CC=1>[OH:8][C:6]1[C:19]2[C:11](=[C:12]([CH3:20])[CH:13]=[C:14]([C:15]([OH:17])=[O:16])[CH:18]=2)[N:10]=[CH:9][CH:5]=1

Participants

3

Reactant 1

HCID 67774099HCID 67774099, compound

Product 1

HCID 178427225HCID 178427225, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Conditions

Temperature
280 °C

Procedure

A mixture of 4-{[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]amino}-3-methylbenzoic acid (10.1 g) and diphenyl ether (101 mL) was heated under stirring in an oil bath at 280° C. for 2 hours. The reaction mixture was returned to room temperature, diluted with petroleum ether and the precipitate was collected by filtration to obtain 4-hydroxy-8-methylquinoline-6-carboxylic acid (6.7 g).

Workup

  1. temperaturewas heated
  2. customwas returned to room temperature
  3. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-c8c8ad091a764acaaf511389e09a95b7
Source dataset
uspto-grants-2014_10
Patent number
US08853242B2

Reaction notes

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