HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-(3-Acetamidophenylamino)-4-(pyrrolidin-3-ylmethylamino)pyrimidine-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 3-((2-(3-acetamidophenylamino)-5-carbamoylpyrimidin-4-ylamino)methyl)pyrrolidine-1-carboxylate | HCID 58098654 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(3-Acetamidophenylamino)-4-(pyrrolidin-3-ylmethylamino)pyrimidine-5-carboxylic acid | HCID 58098802 | — |
Reaction Steps
A solution of tert-butyl 3-((2-(3-acetamidophenylamino)-5-carbamoylpyrimidin-4-ylamino)methyl)pyrrolidine-1-carboxylate (65 mg, 0.138 mmol) in TFA (1 mL) and CH2Cl2 (1 mL) was stirred at room temperature for 2 h. TFA and CH2Cl2 were removed in vacuo. The residue was purified by HPLC to give the titled compound (25 mg). MS 370.3 (M+H); UV 206.4, 244.2 nm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853230B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-ee76d28f3c9c49fca36b63bdd4a2d697 |
| Source note | uspto-grants-2014_10 |