huagongshe.com
HRID533503

反应详情

EQUATION

反应方程式

HRID 533503 的结构方程式

REACTANTS

反应物

3
结构：[Li+].[OH-]
HCID3939

Lithium hydroxide anhydrous

HLiO

结构：CC(CCc1ccc(Br)cc1)(C(=O)O)S(C)(=O)=O
HCID66577906

未命名化合物

结构：CCOC(=O)C(C)(CCc1ccc(B2OC(C)(C)C(C)(C)O2)cc1)S(C)(=O)=O
HCID66578081

未命名化合物

PRODUCTS

生成物

1
结构：CC1(C)OB(c2ccc(CCC(C)(C(=O)O)S(C)(=O)=O)cc2)OC1(C)C
HCID66578008

未命名化合物

收率 112.7%

PROCEDURE

实验过程

The title compound (5.47 g, 100%) was prepared from (+/−)-ethyl 2-methyl-2-(methylsulfonyl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butanoate (5.2 g, 12.7 mmol) and lithium hydroxide (2.13 g, 50.8 mmol) by a procedure analogous to that described for (+/−)-4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid (II/Step 3-Preparation Number 2). LCMS m/z 381.6 (M−1). 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 1.36 (s, 12H) 1.75 (s, 3H) 2.19-2.30 (m, 1H) 2.44-2.55 (m, 1H) 2.56-2.67 (m, 1H) 2.76-2.87 (m, 1H) 3.09 (s, 3H) 7.23 (d, J=8.01 Hz, 2H) 7.76 (d, J=8.20 Hz, 2H).