Lithium Hydroxide → (2R)-2-methyl-2-(methylsulfonyl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butanoic acid

Participants

Role	Name	HCID	Charge
Reactant	Lithium Hydroxide	HCID 3939	—
Reactant	(+/-)-4-(4-Bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid	HCID 66577906	—
Reactant	ethyl (2R)-2-methyl-2-(methylsulfonyl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butanoate	HCID 66577950	—
Product	(2R)-2-methyl-2-(methylsulfonyl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butanoic acid	HCID 66578010	76%

Reaction Steps

The title compound (7.4 g, 76%) was prepared from ethyl (2R)-2-methyl-2-(methylsulfonyl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butanoate (10.5 g, 25.6 mmol) and lithium hydroxide (4.3 g, 102 mmol) by a procedure analogous to that described for (+/−)-4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid as in Preparation 3 step B. LCMS m/z 381.6 (M−1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08853258B2
Source dataset	uspto-grants-2014_10
ORD ID	ord-0860c96279d5451d8e2e9fda8f12ec2a
Source note	uspto-grants-2014_10