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HRID533507

反应详情

EQUATION

反应方程式

HRID 533507 的结构方程式

REACTANTS

反应物

3
结构：[Li+].[OH-]
HCID3939

Lithium hydroxide anhydrous

HLiO

结构：CC(CCc1ccc(Br)cc1)(C(=O)O)S(C)(=O)=O
HCID66577906

未命名化合物

结构：CCOC(=O)[C@@](C)(CCc1ccc(B2OC(C)(C)C(C)(C)O2)cc1)S(C)(=O)=O
HCID66577950

未命名化合物

PRODUCTS

生成物

1
结构：CC1(C)OB(c2ccc(CC[C@](C)(C(=O)O)S(C)(=O)=O)cc2)OC1(C)C
HCID66578010

未命名化合物

收率 76%

PROCEDURE

实验过程

The title compound (7.4 g, 76%) was prepared from ethyl (2R)-2-methyl-2-(methylsulfonyl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butanoate (10.5 g, 25.6 mmol) and lithium hydroxide (4.3 g, 102 mmol) by a procedure analogous to that described for (+/−)-4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid as in Preparation 3 step B. LCMS m/z 381.6 (M−1).