HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 533658Generated: October 29, 2026
Ethylamine → N-Ethyl-5-(trifluoromethyl)pyridin-2-amine
https://huagongshe.com/reaction/533658
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | 2-Chloro-5-(trifluoromethyl)pyridine | HCID 92342 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-Ethyl-5-(trifluoromethyl)pyridin-2-amine | HCID 13144278 | — |
Reaction Steps
A mixture of 2-chloro-5-trifluoromethylpyridine (12 g), 70% of aqueous ethylamine solution (16 ml), and NMP (7 ml) was stirred with heating at 70° C. for 1 day. Into the reaction mixture cooled to room temperature, water was poured, and then the precipitated solid was collected by filtration. The obtained solid was washed with water, and dried to give 6.3 g of N-ethyl-(5-trifluoromethylpyridin-2-yl)-amine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08853238B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-15bed2c7e9a741e4b35fc3538cfc4ca9 |
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| Source note | uspto-grants-2014_10 |
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