Ethylamine → N-Ethyl-5-(trifluoromethyl)pyridin-2-amine

HRID 533658Notes

Reaction equation

HRID 533658 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][N:3]=1.[CH2:12]([NH2:14])[CH3:13].CN1C(=O)CCC1>O>[CH2:12]([NH:14][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][N:3]=1)[CH3:13]

Participants

5

Reactant 3

HCID 6341EthylamineHCID 13387N-methyl-2-pyrrolidoneHCID 923422-Chloro-5-(trifluoromethyl)pyridine

Product 1

HCID 13144278N-Ethyl-5-(trifluoromethyl)pyridin-2-amine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

A mixture of 2-chloro-5-trifluoromethylpyridine (12 g), 70% of aqueous ethylamine solution (16 ml), and NMP (7 ml) was stirred with heating at 70° C. for 1 day. Into the reaction mixture cooled to room temperature, water was poured, and then the precipitated solid was collected by filtration. The obtained solid was washed with water, and dried to give 6.3 g of N-ethyl-(5-trifluoromethylpyridin-2-yl)-amine.

Workup

  1. temperatureInto the reaction mixture cooled to room temperature
  2. filtrationthe precipitated solid was collected by filtration
  3. washThe obtained solid was washed with water
  4. customdried

Sources & evidence

ORD record
ord-15bed2c7e9a741e4b35fc3538cfc4ca9
Source dataset
uspto-grants-2014_10
Patent number
US08853238B2

Reaction notes

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