Hydrogen iodide → HCID 70979807, compound

HRID 533679Notes

Reaction equation

HRID 533679 reaction equation
[CH3:1][CH:2]([CH:6]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15]C)[CH:10]=1)[CH2:7][CH3:8])[C:3]([OH:5])=[O:4].I>>[CH3:1][CH:2]([CH:6]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([OH:15])[CH:10]=1)[CH2:7][CH3:8])[C:3]([OH:5])=[O:4]

Participants

3

Reactant 2

HCID 24841Hydrogen iodideHCID 53353921HCID 53353921, compound

Product 1

HCID 70979807HCID 70979807, compound

Procedure

The steps are: add 2-methyl-3-(3-methoxyphenyl) valeric acid into a reaction flask, add hydroiodic acid, and perform heating and reflux for 12 hours; detect the reaction process by TLC; after that, cool the resultant to the room temperature, pour it into an alkaline solution to make the pH become 9, perform extraction by ethyl acetate, reversely adjust the pH of the water layer to about 3.0 after the water layer is separated out, and add ethyl acetate for extraction; and dry the ethyl acetate extracting solution by anhydrous magnesium sulphate, and recycle the solvent by decompression to obtain a light yellow liquid, 2-methyl-3-(3-hydroxyphenyl) valeric acid.

Workup

  1. temperatureperform heating
  2. temperaturereflux for 12 hours
  3. additionpour it into an alkaline solution
  4. extractionextraction by ethyl acetate
  5. customis separated out
  6. additionadd ethyl acetate
  7. extractionfor extraction
  8. dry with materialand dry the ethyl acetate extracting solution by anhydrous magnesium sulphate

Sources & evidence

ORD record
ord-7a96d4f8385d4b49ad43f25fe5449d0d
Source dataset
uspto-grants-2014_10
Patent number
US08853393B2

Reaction notes

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