HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → N-{[5-(4-iodoquinazoline-6-yl)furan-2-yl]methyl}-2-(methylsulfonyl)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Lithium Bromide | HCID 82050 | — |
| Reactant | HCID 57389674 | HCID 57389674 | — |
| Product | N-{[5-(4-iodoquinazoline-6-yl)furan-2-yl]methyl}-2-(methylsulfonyl)ethanamine | HCID 86671520 | — |
Reaction Steps
The process was repeated as in Example 9 where 1.50 g of sodium iodide (NaI, 10 mmoles) were used instead of LiBr. 3.2 g of N-{[5-(4-iodoquinazoline-6-yl)furan-2-yl]methyl}-2-(methylsulfonyl)ethanamine of formula (VII, X═I) were obtained with a molar yield equivalent to 70%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853396B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-a0bef79add264498bedddd2aa5631ee9 |
| Source note | uspto-grants-2014_10 |