Sodium Iodide → N-{[5-(4-iodoquinazoline-6-yl)furan-2-yl]methyl}-2-(methylsulfonyl)ethanamine

HRID 533700Notes

Reaction equation

HRID 533700 reaction equation
[I-:1].[Na+].[Li+].[Br-].Cl[C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:16]3[O:20][C:19]([CH2:21][NH:22][CH2:23][CH2:24][S:25]([CH3:28])(=[O:27])=[O:26])=[CH:18][CH:17]=3)[CH:14]=2)[N:9]=[CH:8][N:7]=1>>[I:1][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:16]3[O:20][C:19]([CH2:21][NH:22][CH2:23][CH2:24][S:25]([CH3:28])(=[O:27])=[O:26])=[CH:18][CH:17]=3)[CH:14]=2)[N:9]=[CH:8][N:7]=1

Participants

4

Reactant 3

HCID 5238Sodium IodideHCID 82050Lithium BromideHCID 57389674HCID 57389674, compound

Product 1

HCID 86671520N-{[5-(4-iodoquinazoline-6-yl)furan-2-yl]methyl}-2-(methylsulfonyl)ethanamine

Procedure

The process was repeated as in Example 9 where 1.50 g of sodium iodide (NaI, 10 mmoles) were used instead of LiBr. 3.2 g of N-{[5-(4-iodoquinazoline-6-yl)furan-2-yl]methyl}-2-(methylsulfonyl)ethanamine of formula (VII, X═I) were obtained with a molar yield equivalent to 70%.

Sources & evidence

ORD record
ord-a0bef79add264498bedddd2aa5631ee9
Source dataset
uspto-grants-2014_10
Patent number
US08853396B2

Reaction notes

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