反应详情

温度

50 °C

Nalbuphine alkaloid (33.1 g) was charged to a flask containing ethanol (79 ml) and water (20 ml) and the mixture heated to 50° C. Concentrated Hydrochloric acid (9.1 mls) was added to adjust to within the pH range 4-4.5. The resulting solution was cooled to <10° C. using an ice bath and held for ˜2 hours and filtered. The Nalbuphine hydrochloride solid was washed with ethanol:water (10.6 ml:2.6 ml) and dried at 55° C. in a fan oven to afford 35.27 g (89% theory) of Nalbuphine hydrochloride.

1. temperatureThe resulting solution was cooled to <10° C.
2. filtrationfiltered
3. washThe Nalbuphine hydrochloride solid was washed with ethanol
4. dry with materialwater (10.6 ml:2.6 ml) and dried at 55° C. in a fan oven