反应详情

470 mg of 11beta-(4-Acetylphenyl)-17alpha-hydroxy-17-(3-trimethysilyl-2-propinyl)-14beta-estra-4,9-dien-3-one in 24 ml of tetrahydrofuran is mixed with 2.35 ml of a 1M solution of tetrabutylammonium fluoride in tetrahydrofuran and stirred for 5 minutes at room temperature. It is poured on water and extracted with ethyl acetate. The combined organic phases are washed with water, dried on sodium sulfate and concentrated by evaporation. The residue is chromatographed with a mixture of hexane/ethyl acetate on silica gel. 280 mg of the title compound is isolated as foam.

1. additionIt is poured on water
2. extractionextracted with ethyl acetate
3. washThe combined organic phases are washed with water
4. customdried on sodium sulfate
5. concentrationconcentrated by evaporation
6. customThe residue is chromatographed with a mixture of hexane/ethyl acetate on silica gel