Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydroquinone | HCID 785 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Bromo-3-methylbutane | HCID 7891 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 24744926 | HCID 24744926 | — |
Reaction Steps
A mixture of benzene-1,4-diol (20.0 g), DMF (100 mL), cesium carbonate (59.2 g) and 1-bromo-3-methyl-butane (13.7 g) was heated to 60° C. for 12 hours. After the mixture reached room temperature, it was distributed between water and EA. The organic phase was washed twice (water), dried (Na2SO4) and concentrated. The residue was purified by chromatography (SiO2; EA/heptane 1:2) to provide the subtitle compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08853412B2 |
|---|
| Source dataset | uspto-grants-2014_10 |
|---|
| ORD ID | ord-3f8efbc07f614765ada3dcc8102b5ca1 |
|---|
| Source note | uspto-grants-2014_10 |
|---|
