反应详情

温度

60 °C

A mixture of benzene-1,4-diol (20.0 g), DMF (100 mL), cesium carbonate (59.2 g) and 1-bromo-3-methyl-butane (13.7 g) was heated to 60° C. for 12 hours. After the mixture reached room temperature, it was distributed between water and EA. The organic phase was washed twice (water), dried (Na2SO4) and concentrated. The residue was purified by chromatography (SiO2; EA/heptane 1:2) to provide the subtitle compound.

1. customreached room temperature
2. washThe organic phase was washed twice (water)
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated
5. customThe residue was purified by chromatography (SiO2; EA/heptane 1:2)