Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Fluorophenol | HCID 9732 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Bromo-5-hydroxypyridine | HCID 2762865 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | 6-(4-Fluorophenoxy)pyridin-3-ol | HCID 59089027 | — |
Reaction Steps
A mixture of 6-bromo-pyridin-3-ol (8.0 g), 4-fluorophenol (15.5 g) and cesium carbonate (30 g) was heated to 170° C. for 6 hours. After the mixture reached room temperature, it was distributed between water and MTBE. The organic phase was dried (Na2SO4) and concentrated. The residue was purified by chromatography (SiO2; EA/heptane 1:1.5) to provide the subtitle compound. MS ESI+: m/z=206 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08853412B2 |
|---|
| Source dataset | uspto-grants-2014_10 |
|---|
| ORD ID | ord-68a0ea0c070d4f91adbacd02ef8446ae |
|---|
| Source note | uspto-grants-2014_10 |
|---|
