反应详情

温度

170 °C

A mixture of 6-bromo-pyridin-3-ol (8.0 g), 4-fluorophenol (15.5 g) and cesium carbonate (30 g) was heated to 170° C. for 6 hours. After the mixture reached room temperature, it was distributed between water and MTBE. The organic phase was dried (Na2SO4) and concentrated. The residue was purified by chromatography (SiO2; EA/heptane 1:1.5) to provide the subtitle compound. MS ESI+: m/z=206 [M+H]+.

1. customreached room temperature
2. dry with materialThe organic phase was dried (Na2SO4)
3. concentrationconcentrated
4. customThe residue was purified by chromatography (SiO2; EA/heptane 1:1.5)