(3S)-3-hydroxypyrrolidin-2-one → (R)-3-[6-(2-Cyclopropoxy)-pyridin-3-yloxy]-pyrrolidin-2-one

HRID 533902Notes

Reaction equation

HRID 533902 reaction equation
[CH:1]1([O:4][C:5]2[N:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=2)[CH2:3][CH2:2]1.O[C@H:13]1[CH2:17][CH2:16][NH:15][C:14]1=[O:18]>>[CH2:2]1[CH2:3][CH:1]1[O:4][C:5]1[N:10]=[CH:9][C:8]([O:11][C@@H:13]2[CH2:17][CH2:16][NH:15][C:14]2=[O:18])=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 11029774(3S)-3-hydroxypyrrolidin-2-oneHCID 867150946-(Cyclopropyloxy)-3-pyridinol

Product 1

HCID 86715093(R)-3-[6-(2-Cyclopropoxy)-pyridin-3-yloxy]-pyrrolidin-2-one

Procedure

Typical Procedure 3 was followed. Reaction of 6-cyclopropoxy-pyridin-3-ol and (S)-3-hydroxy-pyrrolidin-2-one provided the title compound. MS ESI+: m/z=235 [M+H]+.

Sources & evidence

ORD record
ord-90b87bbab8b24b28975ce8bc264f24dd
Source dataset
uspto-grants-2014_10
Patent number
US08853412B2

Reaction notes

Loading…