HCID 86715098, compound → HCID 86715097, compound

HRID 533906Notes

Reaction equation

HRID 533906 reaction equation
C([O:8][C:9]1[CH:21]=[CH:20][C:12]([O:13][C@@H:14]2[CH2:18][CH2:17][NH:16][C:15]2=[O:19])=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd].CO.C(Cl)Cl>[OH:8][C:9]1[CH:21]=[CH:20][C:12]([O:13][C@@H:14]2[CH2:18][CH2:17][NH:16][C:15]2=[O:19])=[CH:11][CH:10]=1

Participants

4

Reactant 1

HCID 86715098HCID 86715098, compound

Product 1

HCID 86715097HCID 86715097, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21226129Dichloromethane methanolSolvent

Procedure

A mixture of (R)-3-(4-benzyloxy-phenoxy)-pyrrolidin-2-one (61 g), MeOH/DCM (2:1, 2 L) and Pd (10% on carbon, 6 g) was shaken under an atmosphere of hydrogen for 20 hours. The catalyst was removed by filtration and the filtrate concentrated to provide the subtitle compound. MS ESI+: m/z=194 [M+H]+.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-61079ac8544c4126bbe85a195a2c927d
Source dataset
uspto-grants-2014_10
Patent number
US08853412B2

Reaction notes

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