反应详情

A mixture of (S)-3-hydroxy-pyrrolidin-2-one (8.07 g), 6-ethoxypyridin-3-ol (11.0 g) and THF (100 mL) was purged with argon. Triphenylphosphine (20.7 g) was added followed by slow addition of DIAD (16.0 g). After 2 hours the mixture was concentrated and the residue purified by SGC (eluent: EA) to provide the subtitle compound. MS ESI+: m/z=223 [M+H]+.

1. customwas purged with argon
2. additionTriphenylphosphine (20.7 g) was added
3. additionfollowed by slow addition of DIAD (16.0 g)
4. concentrationAfter 2 hours the mixture was concentrated
5. customthe residue purified by SGC (eluent: EA)