(S)-1-(7-Fluoro-3-oxo-indan-5-yl)-3-hydroxy-pyrrolidin-2-one → (R)-3-(2-Bromo-pyridin-4-yloxy)-1-(7-fluoro-3-oxo-indan-5-yl)-pyrrolidin-2-one

HRID 533937Notes

Reaction equation

HRID 533937 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:12]2[CH2:16][CH2:15][C@H:14]([OH:17])[C:13]2=[O:18])[CH:5]=[C:6]2[C:10]=1[CH2:9][CH2:8][C:7]2=[O:11].[Br:19][C:20]1[CH:25]=[C:24](O)[CH:23]=[CH:22][N:21]=1>>[Br:19][C:20]1[CH:25]=[C:24]([O:17][C@@H:14]2[CH2:15][CH2:16][N:12]([C:4]3[CH:5]=[C:6]4[C:10](=[C:2]([F:1])[CH:3]=3)[CH2:9][CH2:8][C:7]4=[O:11])[C:13]2=[O:18])[CH:23]=[CH:22][N:21]=1

Participants

3

Reactant 2

HCID 86715111(S)-1-(7-Fluoro-3-oxo-indan-5-yl)-3-hydroxy-pyrrolidin-2-oneHCID 178516474HCID 178516474, compound

Product 1

HCID 86715123(R)-3-(2-Bromo-pyridin-4-yloxy)-1-(7-fluoro-3-oxo-indan-5-yl)-pyrrolidin-2-one

Procedure

Typical Procedure 3 was followed. Reaction of (S)-1-(7-fluoro-3-oxo-indan-5-yl)-3-hydroxy-pyrrolidin-2-one with 2-bromo-pyridin-4-ol provided the title compound. MS ESI+: m/z=405 [M+H]+.

Sources & evidence

ORD record
ord-c9b1c9058cf94cfc914f9f01440f0da6
Source dataset
uspto-grants-2014_10
Patent number
US08853412B2

Reaction notes

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