(R)-3-((6-(cyclopropylmethoxy)pyridin-3-yl)oxy)pyrrolidin-2-one → (3R)-3-((6-(cyclopropylmethoxy)pyridin-3-yl)oxy)-1-(4,7-difluoro-3-hydroxy-2,3-dihydro-1H-inden-5-yl)pyrrolidin-2-one

HRID 533938Notes

Reaction equation

HRID 533938 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[CH:10][C:9]([O:12][C@@H:13]3[CH2:17][CH2:16][NH:15][C:14]3=[O:18])=[CH:8][CH:7]=2)[CH2:3][CH2:2]1.Br[C:20]1[C:28]([F:29])=[C:27]2[C:23]([CH2:24][CH2:25][CH:26]2[OH:30])=[C:22]([F:31])[CH:21]=1>>[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[CH:10][C:9]([O:12][C@@H:13]3[CH2:17][CH2:16][N:15]([C:20]4[C:28]([F:29])=[C:27]5[C:23](=[C:22]([F:31])[CH:21]=4)[CH2:24][CH2:25][CH:26]5[OH:30])[C:14]3=[O:18])=[CH:8][CH:7]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 86715086(R)-3-((6-(cyclopropylmethoxy)pyridin-3-yl)oxy)pyrrolidin-2-oneHCID 867151256-bromo-4,7-difluoro-2,3-dihydro-1H-inden-1-ol

Product 1

HCID 86715124(3R)-3-((6-(cyclopropylmethoxy)pyridin-3-yl)oxy)-1-(4,7-difluoro-3-hydroxy-2,3-dihydro-1H-inden-5-yl)pyrrolidin-2-one

Procedure

Following Typical Procedure 1 (R)-3-((6-(cyclopropylmethoxy)pyridin-3-yl)oxy)pyrrolidin-2-one was reacted with 6-bromo-4,7-difluoro-2,3-dihydro-1H-inden-1-ol to provide the subtitle compound. MS ESI+: m/z=417 [M+H]+.

Sources & evidence

ORD record
ord-d0f5950fc785424594eff54e11109137
Source dataset
uspto-grants-2014_10
Patent number
US08853412B2

Reaction notes

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