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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 533938Generated: October 30, 2026

(R)-3-((6-(cyclopropylmethoxy)pyridin-3-yl)oxy)pyrrolidin-2-one → (3R)-3-((6-(cyclopropylmethoxy)pyridin-3-yl)oxy)-1-(4,7-difluoro-3-hydroxy-2,3-dihydro-1H-inden-5-yl)pyrrolidin-2-one

https://huagongshe.com/reaction/533938

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-3-((6-(cyclopropylmethoxy)pyridin-3-yl)oxy)pyrrolidin-2-oneHCID 86715086—
Reactant6-bromo-4,7-difluoro-2,3-dihydro-1H-inden-1-olHCID 86715125—
Product(3R)-3-((6-(cyclopropylmethoxy)pyridin-3-yl)oxy)-1-(4,7-difluoro-3-hydroxy-2,3-dihydro-1H-inden-5-yl)pyrrolidin-2-oneHCID 86715124—

Reaction Steps

Following Typical Procedure 1 (R)-3-((6-(cyclopropylmethoxy)pyridin-3-yl)oxy)pyrrolidin-2-one was reacted with 6-bromo-4,7-difluoro-2,3-dihydro-1H-inden-1-ol to provide the subtitle compound. MS ESI+: m/z=417 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08853412B2
Source datasetuspto-grants-2014_10
ORD IDord-d0f5950fc785424594eff54e11109137
Source noteuspto-grants-2014_10