反应详情

To a solution of 3-(4-bromo-2,5-difluorophenyl)acrylic acid (4.20 g) in THF was added chlorotris-(triphenylphosphine)rhodium (400 mg). The mixture was stirred at room temperature under H2-atmosphere for 48 hours. The mixture was filtered and the filtrate was concentrated. The residue was purified by silica gel column chromatography eluting with DCM/petroleum ether (7:1) to give the subtitle compound as a white solid. MS ESI+: m/z=265 [M+H]+.

1. filtrationThe mixture was filtered
2. concentrationthe filtrate was concentrated
3. customThe residue was purified by silica gel column chromatography
4. washeluting with DCM/petroleum ether (7:1)