反应详情

4,5-Diphenyl-thiazol-2-ylamine (50.5 mg, 0.200 mmol) and benzoyl chloride (28.1 mg, 0.200 mmol) were dissolved in 1,4-dioxane (2 mL) containing triethylamine (84.1 μL, 0.600 mmol). The reaction mixture was subjected to microwave irradiation for 5 minutes at 200° C. The crude product was filtered, evaporated to dryness, dissolved in 1 mL of dimethylsulfoxide and purified by reverse-phase preparative liquid chromatography (7.21 mg, 0.0202 mmol, 10.1%). ESI-MS m/z calc. 356.1. found 357.2 (M+1)+ Retention time 3.95 minutes.

1. customirradiation for 5 minutes at 200° C
2. filtrationThe crude product was filtered
3. customevaporated to dryness
4. dissolutiondissolved in 1 mL of dimethylsulfoxide
5. custompurified by reverse-phase preparative liquid chromatography (7.21 mg, 0.0202 mmol, 10.1%)