HCID 67486330, compound → HCID 67486723, compound

HRID 534004Notes

Reaction equation

HRID 534004 reaction equation
C([O:8][C:9]1[CH:10]=[N:11][N:12]([CH2:14][CH2:15][OH:16])[CH:13]=1)C1C=CC=CC=1.[H][H]>C1COCC1.[Pd]>[OH:16][CH2:15][CH2:14][N:12]1[CH:13]=[C:9]([OH:8])[CH:10]=[N:11]1

Participants

5

Reactant 2

HCID 67486330HCID 67486330, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67486723HCID 67486723, compoundYield 169.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

2-(4-(benzyloxy)-1H-pyrazol-1-yl)ethanol (1.81 g, 8.3 mmol) was dissolved in THF (15 mL) under nitrogen. Pd/C (0.22 g, 0.21 mmol) was added and the solution was placed under vacuum and charged with a hydrogen balloon. The mixture stirred at ambient temperature overnight under this hydrogen atmosphere. The solution was filtered through GF/F paper and concentrated to give 1-(2-hydroxyethyl)-1H-pyrazol-4-ol (1.8 g, quantitative).

Workup

  1. filtrationThe solution was filtered through GF/F paper
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-a1e45de0f15f462f9443b09d8723a0f1
Source dataset
uspto-grants-2014_10
Patent number
US08853409B2

Reaction notes

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