HCID 86644151, compound → 2-Ethylpyridin-3-yl acetate

HRID 534023Notes

Reaction equation

HRID 534023 reaction equation
[C:1]([O:4][C:5]1[C:6]([C:11]#[CH:12])=[N:7][CH:8]=[CH:9][CH:10]=1)(=[O:3])[CH3:2]>C(O)C.O=[Pt]=O>[C:1]([O:4][C:5]1[C:6]([CH2:11][CH3:12])=[N:7][CH:8]=[CH:9][CH:10]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 86644151HCID 86644151, compound

Product 1

HCID 671213462-Ethylpyridin-3-yl acetateYield 100%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

To a solution of 2-ethynylpyridin-3-yl acetate (5.0 g, 31 mmol) in ethanol (50 mL) was added PtO2 (0.50 g, 2.2 mmol). The mixture was degassed with nitrogen and placed under a double-layer balloon of hydrogen. The reaction was stirred at ambient temperature for 30 minutes, then filtered and concentrated in vacuo to give 2-ethylpyridin-3-yl acetate (5.1 g, 31 mmol) which was used in the next step without further purification.

Workup

  1. customThe mixture was degassed with nitrogen
  2. filtrationfiltered
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-87508fbac82d4b5089508e6448ef3bce
Source dataset
uspto-grants-2014_10
Patent number
US08853409B2

Reaction notes

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