反应详情

To a stirred solution of 2-iodo benzene sulfonamide (4 g) in acetone (40 mi) solid K2CO3 (3.92 g) is added in one portion and the mixture is refluxed under N2 -atmosphere, n-propyl isocyanate is added dropwise to the heated mixture. After 2 hours reflux, the reaction is cooled to room temperature and concentrated to dryness. Water (200 ml) is added and the cooled mixture is acidified with 2N HCl to pH 4 and filtered. The precipitate obtained is recristallised with acetone/isopropyl ether mixture to give 4.1 g solid of the title compound.

1. temperaturethe mixture is refluxed under N2 -atmosphere
2. temperatureAfter 2 hours reflux
3. concentrationconcentrated to dryness
4. additionWater (200 ml) is added
5. filtrationfiltered
6. customThe precipitate obtained