HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 17beta-Benzoyl-estra-1,3,5(10)-triene-3-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 17beta-benzoyl-estra-1,3,5(10)-triene-3-carboxylate | HCID 54345982 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 17beta-Benzoyl-estra-1,3,5(10)-triene-3-carboxylic Acid | HCID 9886601 | — |
Reaction Steps
A mixture of methyl 17β-benzoyl-estra-1,3,5(10)-triene-3-carboxylate, K2CO3, water and methanol is heated at reflux for 5 h. The volatiles are then removed at reduced pressure and the residue is diluted with water, acidified with dilute aqueous HCl, and extracted with EtOAc. The organic extract is washed with water and brine, dried, and evaporated to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05618806 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-e1717645044a464f8aa75e660cd0f8f3 |
| Source note | uspto-grants-1997_04 |