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HRID53447

反应详情

EQUATION

反应方程式

HRID 53447 的结构方程式

REACTANTS

反应物

3
结构：O
HCID962

Water

H2O

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：COC(=O)c1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](C(=O)c3ccccc3)CC[C@@H]12
HCID54345982

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]12CC[C@@H]3c4ccc(C(=O)O)cc4CC[C@H]3[C@@H]1CC[C@@H]2C(=O)c1ccccc1
HCID9886601

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A mixture of methyl 17β-benzoyl-estra-1,3,5(10)-triene-3-carboxylate, K2CO3, water and methanol is heated at reflux for 5 h. The volatiles are then removed at reduced pressure and the residue is diluted with water, acidified with dilute aqueous HCl, and extracted with EtOAc. The organic extract is washed with water and brine, dried, and evaporated to yield the title compound.

WORKUP

后处理

  1. temperatureis heated
  2. temperatureat reflux for 5 h
  3. customThe volatiles are then removed at reduced pressure
  4. additionthe residue is diluted with water
  5. extractionextracted with EtOAc
  6. extractionThe organic extract
  7. washis washed with water and brine
  8. customdried
  9. customevaporated