Sodium Hydroxide → HCID 54349141, compound

HRID 53454Notes

Reaction equation

HRID 53454 reaction equation
[C:1]([C@H:9]1[CH2:14][CH2:13][C@H:12]2[C@H:15]3[C@H:24]([CH2:25][CH2:26][C@:10]12[CH3:11])[C:23]1[CH:22]=[CH:21][C:20]([C:27]([OH:29])=[O:28])=[CH:19][C:18]=1[CH2:17][CH2:16]3)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CS(C)=O>[C:1]([C@@H:9]1[CH2:14][CH2:13][C@H:12]2[C@H:15]3[C@H:24]([CH2:25][CH2:26][C@:10]12[CH3:11])[C:23]1[CH:22]=[CH:21][C:20]([C:27]([OH:29])=[O:28])=[CH:19][C:18]=1[CH2:17][CH2:16]3)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 988660117beta-Benzoyl-estra-1,3,5(10)-triene-3-carboxylic Acid

Product 1

HCID 54349141HCID 54349141, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Into a 250 ml 3-neck round bottom flask is placed 17β-Benzoyl-estra-1,3,5(10)-triene-3-carboxylic acid and an excess of sodium hydroxide. To the flask is added dimethyl sulfoxide as a solvent. The mixture is heated to reflux for 3 hours. Standard workup followed by isolation by preparative HPLC yields title compound.

Workup

  1. customInto a 250 ml 3-neck round bottom flask is placed
  2. temperatureThe mixture is heated
  3. temperatureto reflux for 3 hours

Sources & evidence

ORD record
ord-83c636ab3bb549998c6a6c73a0e2a87c
Source dataset
uspto-grants-1997_04
Patent number
US05618806

Reaction notes

Loading…