反应详情

To a solution of N-benzyl-O-benzyl-N2-Boc-D-serinamide (1 g) and dichloromethane (5 mL), aq.HCl (35%) (5 mL) was added. The solution was stirred for 2 hours at room temperature for completion of reaction. The solution was concentrated under vacuum to remove dichloromethane and subsequently water was added. The aqueous layer was basified to pH 8-10 with 5% sodium hydroxide. The aqueous layer was extracted with ethyl acetate and the combined organic layer was washed with brine solution. Organic layer was concentrated under vacuum to obtain an oily residue 0.46 g of N-benzyl-β-benzyl-D-serinamide.

1. concentrationThe solution was concentrated under vacuum
2. customto remove dichloromethane and subsequently water
3. additionwas added
4. extractionThe aqueous layer was extracted with ethyl acetate
5. washthe combined organic layer was washed with brine solution
6. concentrationOrganic layer was concentrated under vacuum